李婷,女,副教授,博士生导师。入选2023年度陕西省青年科技新星。主持国家自然科学基金项目3项(面上2项,青年1项)、中国博士后科学基金2项(特别资助和面上项目各1项)、陕西省科协青年人才托举计划项目1项、陕西省科技攻关项目1项、中央高校科研业务基金2项;先后在Cell Metabolism等SCI杂志发表论文40余篇;参编教材2部;参与获得陕西省科技进步二等奖1项、陕西高等学校科学技术一等奖和二等奖各1项。主要从事功能食品与分子营养学领域相关教学与科研工作。
邮箱:tingli@snnu.edu.cn
教育经历
2014.09-2017.11,香港浸会大学,中药学博士(导师禹志领教授)
2011.09-2014.07,陕西师范大学,食品科学硕士(导师杨兴斌教授)
2007.09-2011.07,西北农林科技大学,食品质量与安全专业学士
主要研究方向:
1. 功能食品活性成分及营养功效研究
2. 膳食-宿主-肠道菌群互作机制研究
3. 特膳食品研究
主持科技项目:
1. 国家自然科学基金面上项目(32472343),功能性寡糖触发小肠上皮细胞HSP90β-PI3K-Akt信号级联保护黏膜屏障的分子机制,主持
2. 陕西师范大学优秀青年人才项目(GK202309004),功能性低聚糖调控小肠外泌体miRNA谱新功能的构效关系研究,主持
3. 陕西省科协青年人才托举计划项目(20220218),益生元水苏糖调控小肠上皮细胞外泌体miRNA表达谱的新功能,主持
4. 国家自然科学基金面上项目(32272309),功能低聚糖调控小肠上皮细胞外泌体miRNA谱的新功能及分子机制,主持
5. 中国博士后科学基金特别资助项目(2020T130395),基于益生元水苏糖探究靶向改善肠道内环境的小肠miRNA及其分子机制,主持
6. 国家自然科学基金青年项目(31901702),小肠上皮细胞microRNA介导水苏糖调控肠道菌群的分子机制研究,主持
7. 中国博士后科学基金面上项目(2019M653535),基于小肠miRNA表达谱探究水苏糖改善肠环境的分子机制,主持
8. 陕西省重点研发计划一般项目-农业领域(2019NY-125),猕猴桃微生态发酵制品及关键技术研发与示范,主持
代表性研究论文:
1. Ting Li*, Yueyue Liu, Tianchi Duan, Chao Guo, Bin Liu, Xiuqiong Fu, Lu Wang, Xiaoyuan Wang, Xinyue Dong, Chennan Wang, Yalong Lu, Yu Wang, Lin Shi, Honglei Tian, Xingbin Yang*. Nondigestible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: a new function & mechanism. Cell Metabolism, 2024(TOP Q1,IF 27.7)
2. Zhang YY, Qi BR, Li QN, Yang CC, Yu PL, Yang XB*, Li T*. Dynamic changes on sensory property, nutritional quality and metabolic profiles of green kernel black beans during Eurotium Cristatum-based solid-state fermentation. Food Chemistry, 2024, 455.(TOP Q1,IF 8.5)
3. Wang XY, Liu YY, Dong XY, Duan TC, Wang CN, Wang L, Yang XB, Tian HL, Li T*. peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron. Pharmacological Research, 2024, 200: 107071.(TOP Q1,IF 9.1)
4. Duan TC, Wang XY, Dong XY, Wang CN, Wang L, Yang XB, Li T*. Broccoli-derived exosome-like nanoparticles alleviate loperamide induced constipation, in correlation with regulation on gut microbiota and tryptophan metabolism. Journal of Agricultural and Food Chemistry, 2023, 71, 16568-16580.(TOP Q1,封面论文)
5. Dong XY, Liu YY, Yang XB, Li T*. Extracellular vesicle miRNAs as key mediators in diet-gut microbiome-host interplay. Trends in Food Science & Technology, 2023, 136: 268-281.(TOP Q1,IF 15.1)
6. Zhang XN, Li QN, Han N, Song CF, Lin YN, Zhang LS, Ren DY, Zhao Y, Yang XB* and Li T*. Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites of HFD/STZ-induced type 2 diabetes rats. Food & Function, 2023, 14, 10910-10923.(TOP Q1)
7. Wang Y, Li Ting*, Liu YY, Yang CC, Liu L, Zhang XN, Yang XB*. Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet. Food & Function, 2023, 12: 13014-13027. (TOP Q1)
8. Wang XY, Liu YY, Wang Y, Dong XY, Wang YH, Yang XB, Tian HL, Li Ting*. Protective effect of coriander (Coriandrum sativum L.) on high-fructose and high-salt diet-induced hypertension: relevant to improvement of renal and intestinal function. Journal of Agricultural and Food Chemistry, 2022;70: 3730-3744.(TOP Q1)
9. Li Ting, Fu XQ, Liu B, Wang XY, Li JK, Zhu PL, Niu XD, Bai JX, Liu YX, Lu XS, Yu ZL*. Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models. Biochemical Pharmacology, 2022;200:115044.(TOP Q1)
10. 李婷, 田洪磊, 杨兴斌*. miRNA-肠道微生物轴与机体健康. 未来食品科学, 2022;2(1): 54-64.
11. Du HP, Wang Q, Li Ting*, Ren DY, Yang XB*. Grape seed proanthocyanidins reduced the overweight of C57BL/6J mice through modulating adipose thermogenesis and gut microbiota. Food & Function, 2021;12(18): 8467-8477.(TOP Q1)
12. Alim A, Li Ting*, Nisar T, Ren DY, Liu YY, Yang XB. Consumption of two whole kiwifruit (Actinide chinensis) per day improves lipid homeostasis, fatty acid metabolism and gut microbiota in healthy rats. International Journal of Biological Macromolecules, 2020;156: 186.(TOP Q1)
13. Liu YY, Li Ting*, Alim A, Ren DY, Zhao Y, Yang XB*. Regulatory effects of stachyose on colonic and hepatic inflammation, gut microbiota dysbiosis, and peripheral CD4+ T cell distribution abnormality in high-fat diet-fed mice. Journal of Agricultural and Food Chemistry, 2019;67:11665-11674.(TOP Q1)
14. Liu YX#, Bai JX#, Li Ting#, Fu XQ, Guo H, Zhu PL, Chan YC, Chou JY, Yin CL, Li JK, Wang YP, Chen YJ, Yu ZL*. A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment. Pharmacological Research, 2019;142:115-126.(TOP Q1)
15. Alim A, Li Ting*, Nisar T, Ren DY, Zhai XC, Pang YX, Yang XB*, Antioxidant, antimicrobial, and antiproliferative activity-based comparative study of peel and flesh polyphenols from Actinidia chinensis, Food & Nutrition Research, 2019;26:63.
16. Li Ting, Lu XS, Yang XB. Evaluation of clinical safety and beneficial effects of stachyose-enriched α-galacto-oligosaccharides on gut microbiota and bowel function in humans. Food & Function, 2017;8(1):262-269.(TOP Q1)
17. Li Ting, Fu XQ, Tse AK, Guo H, Lee KW, Liu B, Su T, Wang XY, Yu ZL. Inhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos. Scientific Reports, 2017;7(1):3097.
18. Li Ting, Lu XS, Sun YF, Yang XB. Effects of spinach nitrate on insulin resistance, endothelial dysfunction markers and inflammation in mice with high-fat and high-fructose consumption. Food & Nutrition Research, 2016;60:32010.
19. Li Ting, Lu XS, Yang XB. Stachyose-enriched galacto-oligosaccharides regulate gut microbiota and relieve constipation in mice. Journal of Agricultural and Food Chemistry, 2013;61(48):11825-11831.(TOP Q1)
20. Li Ting, Zhu J, Guo L, Shi XL, Liu YF, Yang XB. Differential effects of polyphenols-enriched extracts from hawthorn fruit peels and fleshes on cell cycle and apoptosis in human MCF-7 breast carcinoma cells. Food Chemistry, 2013;141:1008-1018. (TOP Q1)